ISA2021

Program

(Last updated September 27, 2021)

Plenary Lecture

Plenary Symposium

Symposium

Joint Symposium

Satellite Symposium

Morning Seminar

Luncheon Seminar

Sponsored Symposium

ISA2021 Program will be held in live streaming.
Also, the record of the sessions will be available as the on-demand until November 30, 2021.
Please understand that not all sessions will be available for live streaming and on-demand.

Plenary Lecture

Achieving Productive Aging
- The Systemic Regulatory Mechanism of Mammalian Aging and Longevity and Anti-Aging Intervention -

Shin-ichiro IMAI(Washington University School of Medicine / Institute of Biomedical Research and Innovation, USA/Japan)
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Plenary Symposium

Plenary Symposium 1

"Hypertension/ Kidney Disease"
Systemic Hemodynamic Atherothrombotic Syndrome and Resonance Hypothesis of Blood Pressure Variability: Triggering Cardiovascular Events

10/25 (Mon.) 10:15-11:45 (JST) Room 2 (ICC Kyoto Room A)

Chair
Hiromi RAKUGI(Department of Geriatric and General Medicine, Osaka University, Japan)
Nagako OKUDA(Department of Health Science, Kyoto Prefectural University, Japan)
"Systemic Hemodynamic Atherothrombotic Syndrome and Resonance Hypothesis of Blood Pressure Variability: Triggering Cardiovascular Events"
Kazuomi KARIO(Jichi Medical University School of Medicine, Japan)
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"Management of Hypertension in the Older Patients with an Understanding of the SHATS Concept"
Hiromi RAKUGI(Department of Geriatric and General Medicine, Osaka University, Japan)
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"Nutrition, Hypertension and Cardiovascular Diseases; Importance and Feasibility of Dietary Na/K Improvement"
Nagako OKUDA(Department of Health Science, Kyoto Prefectural University, Japan)
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Plenary Symposium 2

"Lipid"
Novel Development of Lipid Lowering Drug

10/25 (Mon.) 17:40-19:40 (JST) Room 2 (ICC Kyoto Room A)

Chair
Kausik RAY(Department of Primary Care and Public Health, Imperial College London, UK)
Mariko HARADA-SHIBA(Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute, Japan)
"Inclisiran"
Kausik RAY(Department of Primary Care and Public Health, Imperial College London, UK)
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"Current and Future Treatment For Severe Heterozygous and Homozygous FH"
Frederick RAAL(Endocrinology, Department of Medicine, University of the Witwatersrand, South Africa)
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"ApoC3 vs ANGPTL3 inhibition for Severe Hypertriglyceridemia"
Daniel GAUDET(Universite de Montreal and Ecogene-21, Canada)
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"Antisense Inhibition of Lp(a)"
Sotirios TSIMIKAS(University of California San Diego School of Medicine, USA)
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"Bempedoic Acid"
Christie BALLANTYNE(Department of Medicine, Baylor College of Medicine, USA)
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"Selective Peroxisome Proliferator-Activated Receptor Alpha Modulator (Spparmα): The Novel Strategy To Reduce Residual Cardiovascular Risk"
Shun ISHIBASHI(Department of Internal Medicine, Jichi Medical University, Japan)
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Plenary Symposium 3

"Diabetes"
Effects of Comprehensive Management of Type 2 Diabetes on Long Term Prognosis

10/25 (Mon.) 17:40-19:10 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Kohjiro UEKI(National Center for Global Health and Medicine, Japan)
Kouji KAJINAMI(Kanazawa Medical University, Japan)
"Multiple Risk Factor Management of Diabetes For Prevention of CVD"
Nathan D. WONG(Heart Disease Prevention Program, University of California, Irvine, USA)
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"Steno-2 Study: What We Have Learned From 21-Years of Intensive, Multiple Risk Factor Intervention in Type 2 Diabetes"
Peter GAEDE(Department of Cardiology and Endocrinology, Slagelse Hospital, Denmark)
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"J-DOIT3-Effect of an Intensified Multifactorial Intervention on Cardiovascular and Renal Outcomes and Mortality in Type 2 Diabetes"
Takashi KADOWAKI(The University of Tokyo/ Toranomon Hospital, Japan)
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Plenary Symposium 4

"Lipid"
HDL and Reverse Cholesterol Transport
-Prospect for Antiatherogenic Agent Associated with HDL Metabolism-

10/26 (Tue.) 7:45-9:15 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Katsunori IKEWAKI(Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Japan)
Kerry-Anne RYE(School of Medical Science, University of New South Wales, Australia)
"HDL Heterogeneity and Differential Cardiovascular Risk to Find a Specific Treatment Target"
Shinji YOKOYAMA(Institute for Biological Functions, Chubu University, Japan)
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Daniel J RADER(Pennsylvania University, USA)
"HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease"
Anatol KONTUSH(INSERM Research Unit 1166, Sorbonne University, France)
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"A Novel Anti-oxidant Role for Apolipoprotein A-I in Diabetes"
Kerry-Anne RYE(School of Medical Science, University of New South Wales, Australia)
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"Novel Strategy for Prevention of Cardiovascular Disease by Increasing CETP and Enhancing Reverse Cholesterol Transport (RCT) with Probucol"
Shizuya YAMASHITA(Department of Cardiology, Rinku General Medical Center, Japan)
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Plenary Symposium 5

"Epidemiology"
New Era of Pharmacological Therapy for Coronary Artery Disease

10/26 (Tue.) 18:10-19:40 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Dong ZHAO(Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital-Beijing Institute of Heart,Lung & Blood Vessel Diseases, China)
Katsumi MIYAUCHI(Department of Cardiology, Juntendo Tokyo Koto Geriatric Medical Center, Japan)
"Are There Controversies on LDL-C Level and Mortality?"
Lale TOKGÖZOGLU(Department of Cardiology, Hacettepe University, Turkey)
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Jennifer ROBINSON(Department of Epidemiology, University of Iowa, USA)
"The Role of N-3 Polyunsaturated Fatty Acid for the Cardiovascular Disease Prevention; Where Are We Now?"
Hiroyuki DAIDA(Faculty of Health Science, Juntendo University, Japan)
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"Rivaroxaban, a Direct Oral Anticoagulant, Attenuates Atherosclerotic Plaque Progression and Destabilization by Inhibiting FXa-PAR2 Pathway"
Masataka SATA(University of Tokushima Graduate School, Japan)
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Plenary Symposium 6

"Lipid" Cholesterol Homeostasis

10/27 (Wed.) 16:30-18:00 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Hitoshi SHIMANO(Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Japan)
Sumiko ABE-DOHMAE(Chubu University, Japan)
"A New Role of De Novo Synthesized Cholesterol in Plasma Membrane ~ A Lesson From Muscle-Specific Hmgcoar Knockout Mice"
Hitoshi SHIMANO(Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Japan)
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"Transintestinal Cholesterol Excretion A Promising Pathway to Target Dyslipidemia."
Albert K. GROEN(Department of Experimental Vascular Medicine, Amsterdam University Medical Centers, Netherlands)
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"The Relative Contributions of Hepatobiliary and Intestinal Pathways to Cholesterol Excretion"
Gregory GRAF(Pharmaceutical Sciences Department, University of Kentucky, USA)
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Plenary Symposium 7

"Epidemiology Big Data"
Big Data Analysis for Adequate Decision Making to Prevent Atherosclerotic Diseases

10/27 (Wed.) 16:30-18:00 (JST) Room 2 (ICC Kyoto Room A)

Chair
Tomonori OKAMURA(Preventive Medicine and Public Health, Keio University School of Medicine, Japan)
Anne TYBJAERG-HANSEN(Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark)
"Individual Participant Data Meta-Analysis of Cohort Studies on Cardiovascular Diseases in Japan: EPOCH-JAPAN"
Yoshitaka MURAKAMI(Department of Medical Statistics, Toho University, Japan)
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"Metabolic Profiling in Population-Based Cohort Studies and Prevention of Atherosclerosis"
Toru TAKEBAYASHI(Keio University, Japan)
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"Polygenic Risk Scores in Dyslipidemia and CAD"
Anne TYBJAERG-HANSEN(Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark)
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"Nutrition and Metabolomics in Epidemiologic Studies"
Paul ELLIOTT(School of Public Health, Imperial College London, UK)
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Symposium

Symposium 1

"Lipid" Awareness of FH

10/25 (Mon.) 8:40-10:10 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Masatsune OGURA(Chiba University, Japan)
Mary MCGOWAN(The FH Foundation, USA)
Mary MCGOWAN(The FH Foundation)
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"Awareness of Familial Hypercholesterolemia in Iberoamerica"
Rodrigo ALONSO(Center for Advanced Metabolic Medicine and Nutrition, Chile)
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"Familial Hypercholesterolemia Awareness in North America–A Work in Progress"
Anne GOLDBERG(Department of Internal Medicine, Washington University School of Medicine, USA)
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"Awareness of FH In Japan"
Masatsune OGURA(Chiba University, Japan)
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"Fine Tuning for Accurate and Differential Diagnosis of FH Through Genetic Analysis"
Hayato TADA(Kanazawa University, Japan)
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Symposium 2

"Diabetes" New Horizon for Basic Research on Diabetic Complications

10/25 (Mon.) 8:40-10:10 (JST) Room 2 (ICC Kyoto Room A)

Chair
Yasushi ISHIGAKI(Department of Diabetes, Metabolism and Endocrinology, Iwate Medical University, Japan)
Aruna PRADHAN(Harvard Medical School, Brigham and Women’s Hospital, USA)
"Renal Energy Metabolism as a Promising Therapeutic Target for Diabetic Kidney Disease"
Shinji KUME(Department of Medicine, Shiga University of Medical Science, Japan)
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"Pathophysiology of Diabetic Retinopathy"
Akiyoshi UEMURA(Nagoya City University, Japan)
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"Diabetic Complications and Aging Related Genes"
Yoshiro MAEZAWA(Department of Endocrinology, Hematology And Gerontology, Chiba University Graduate School of Medicine, Japan)
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"Pemafibrate, a Selective PPAR-a Modulator for Prevention of Cardiovascular Events in Type 2 Diabetes"
Aruna PRADHAN(Harvard Medical School and Brigham and Women’s Hospital, USA)
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Symposium 3

Obesity, Metabolic Syndrome

10/25 (Mon.) 8:40-10:10 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Philipp E. SCHERER(Touchstone Diabetes Center, Internal Medicine, The University of Texas Southwestern Medical Center, USA)
Noriko SATOH-ASAHARA(Department of Endocrinology, Metabolism, and Hypertension Research, National Hospital Organization Kyoto Medical Center, Japan)
"Pathological Significance of Monocyte/Macrophage/Microglia Phenotypes in Metabolic Syndrome and Cerebrocardiovascular Complications"
Noriko SATOH-ASAHARA(Department of Endocrinology, Metabolism, and Hypertension Research, National Hospital Organization Kyoto Medical Center, Japan)
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"Impact of Obesity on Cardiovascular Disease, Are There Differences Related to Sex?"
Ada CUEVAS(Center for Advanced Metabolic Medicine and Nutrition (cammyn), Chile)
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"Adiponectin / T-cadherin System for the Protection of Cardiovascular Renal Diseases through Exosome Production and Mesenchymal Stem Cells"
Iichiro SHIMOMURA(Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Japan)
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"Adipose Tissues and Whole Body Homeostasis"
Philipp E. SCHERER(The University of Texas Southwestern Medical Center, USA)
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Symposium 4

"COVID-19" COVID-19 Pandemic Impact on Cardiovascular Diseases

10/25 (Mon.) 10:15-11:45 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Eriko MORISHITA(Kanazawa University, Japan)
Keith FERDINAND(Tulane University School of Medicine, USA)
"COVID-19-Associated Coagulopathy"
Eriko MORISHITA(Kanazawa University, Japan)
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Keith FERDINAND(Tulane University School of Medicine, USA)
"Systemic endothelial dysfunction: a key pathophysiological explanation of fatal outcome in COVID-19?"
Atsushi TANAKA(Department of Cardiovascular Medicine, Saga University, Japan)
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Symposium 5

"NASH" NAFLD/NASH and Cardiovascular Diseases

10/25 (Mon.) 10:15-11:45 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Hitoshi SHIMANO(Department of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Japan)
Rebecca HAEUSLER(Department of Pathology and Cell Biology, Colombia University, USA)
"Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH) and Cardiovascular Diseases"
Zobair M YOUNOSSI(Department of Medicine, Inova Fairfax Medical Campus, USA)
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"Pemafibrate, a Selective Peroxisome Proliferator-Activated Receptor Alpha Modulator (SPPARM Alpha), Improves Liver Stiffness by MRE and Serum Liver and Lipid Parameters in NAFLD; a Randomized, Double-blind, Placebo-Controlled Phase 2 Trial (PEMA-FL Study)"
Atsushi NAKAJIMA(Department of Gastroenterology and Hepatology, Yokohama City University, Japan)
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"Pathophysiological Interplay Between NAFLD/NASH and Cardiovascular Disease: Is There a Role of PCSK9 Modulation?"
Paolo MAGNI(Department of Pharmacological and Biomolecular Sciences, Universita' degli Studi di Milano, and IRCCS MultiMedica, Milan, Italy)
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"Cyp2C-Deficiency Depletes Muricholic Acids and Protects Against High Fat Diet-Induced Obesity in Male Mice But Promotes Liver Fibrosis"
Rebecca HAEUSLER(Department of Pathology and Cell Biology, Colombia University, USA)
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"Steatohepatitis-related Cardiomyopathy in a Rodent Model"
Masahiro KOSEKI(Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan)
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Symposium 6

"Hypertension"
Management of Cardiovascular Diseases by Mineralocorticoid Receptor Antagonist: Above and Beyond

10/25 (Mon.) 13:15-14:45 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Mitsuru OHISHI(Kagoshima University, Japan)
Mari NISHIZAKA(Department of Cardiovascular Medicine, Fukuoka Sanno Hospital, Japan)
"Pathophysiological Mechanism of Mineralocorticoid Receptor-Dependent Hypertension and Chronic Kidney Disease"
Akira NISHIYAMA(Department of Pharmacology, Kagawa University Medical School, Japan)
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"The Pathophysiological Role of Mineralocorticoid Receptor in Heart Failure."
Tomohisa NAGOSHI(Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan)
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"Revisiting Primary Aldosteronism: Standardization of Aldosterone Measurement and Mineralocorticoid Receptor-Associated Hypertension"
Hirotaka SHIBATA(Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Oita University Faculty of Medicine, Japan)
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"Aldosterone, Resistant Hypertension, and Sleep Apnea Syndrome"
Mari NISHIZAKA(Department of Cardiovascular Medicine, Fukuoka Sanno Hospital, Japan)
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Symposium 7

"Aging"
Public and Patient Education to Prevent Atherosclerotic Diseases in Asia

10/25 (Mon.) 13:15-14:45 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Takumi HIRATA(Department of Public Health, Hokkaido University Faculty of Medicine, Japan)
Naomi MIYAMATSU(Shiga University of Medical Science, Japan)
"Recent Lipid Management for the Prevention of Atherosclerotic Cardiovascular Diseases in Asia"
Akira FUJIYOSHI(Wakayama Medical University, Japan)
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"Current Epidemiology of Cardiovascular Disease and Its  Risk Factors  in Bangladesh"
Sohel CHOUDHURY(National Heart Foundation Hospital and Research Institute, Bangladesh)
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"Community-Based Health Promotion Activities for Cardiovascular Disease Prevention in Japan and Indonesia: A Nursing Perspective"
Mayumi MIZUTANI(Department of Public Health Nursing, Mie University Graduate School of Medicine, Japan)
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"Health Guidance for Life-Style Related Diseases to Prevent Atherosclerotic CVD"
Mai KABAYAMA(Department of Health Sciences Health, Osaka University Graduate School of Medicine, Japan)
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Symposium 8

"Diabetes"

10/25 (Mon.) 16:00-17:30 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Kyoko INAGAKI(Department of Endocrinology, Diabetes and Metabolism, Nippon Medical School, Japan)
Christoph WANNER(Division of Nephrology, University Hospital of Würzburg, Germany)
"Finerenone in Diabetic Kidney Disease"
George BAKRIS(Faculty of Medicine, The University of Chicago Medicine, USA)
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"Effects of SGLT2 Inhibitors on DKD"
Christoph WANNER(Division of Nephrology, University Hospital Würzburg, Germany)
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"Targeting Incretin System for the Treatment of Diabetes"
Yuichiro YAMADA(Kansai Electric Power Hospital, Japan)
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"Incidence and Risk Factors for Hypertension Disorder in Pregnant Women with or without Gestational Diabetes Mellitus; A Retrospective Single-Center Analysis "
Yuka MATOBA(Department of Diabetes, Endocrinology and Metabolism, National Hospital Organization Kokura Medical Center, Japan)
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Symposium 9

"Aging" Basic

10/25 (Mon.) 16:00-17:30 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Tohru MINAMINO(Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Japan)
"Impact of Aging on the Vascular Niche: The Importance of Cellular Communication"
Stefanie DIMMELER(Institute of Cardiovascular Regeneration, Institute for Molecular Medicine, Goethe-University Frankfurt, Germany)
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"Vascular Endothelial Stem Cells in Health and Ageing"
Nobuyuki TAKAKURA(Department of Signal Transduction, RIMD, Osaka University, Japan)
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"Age-Related Mutations and Clonal Hematopoiesis in Atherosclerosis: Beyond Conventional Cardiovascular Risk Factors."
Jose FUSTER(Spanish National Center For Cardiovascular Research (CNIC), Spain)
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"Macrophage Cellular Cholesterol as a Novel Therapeutic Target of Atherosclerosis"
Yumiko OISHI(Nippon Medical School, Japan)
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"Pathological Roles of Senocules in Sync-Aging and Cardiovascular Disorders"
Ippei SHIMIZU(Department of Cardiovascular Biology and Medicine, Juntendo University, Japan)
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Symposium 10

Diet Pattern and CVD

10/26 (Tue.) 7:45-9:15 (JST) Room 2 (ICC Kyoto Room A)

Chair
Masako WAKI(Food Safety Commission, Cabinet Office, Japan)
Chizuko MARUYAMA(Department of Food and Nutrition, Japan Women's University, Japan)
"Healthful Dietary Patterns to Prevent and Alleviate Chronic Disease"
Frank M SACKS(Department of Nutrition, Harvard T.H. Chan School Of Public Health, USA)
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"Mediterranean Diet, Extra Virgin Olive Oil and Cardiovascular Risk"
Jasmine Frances MILLMAN(Second Department of Internal Medicine, University of the Ryukyus, Japan)
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"Healthy Diet in Vietnamese"
Nguyet Thu NGHIEM(Department of Clinical Nutrition And Dietetics, National Institute of Nutrition, Vietnam)
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"The Japan Diet: Recommended by the Japan Atherosclerosis Society"
Noriko KAMEYAMA(School of Food and Nutritional Sciences, University of Shizuoka, Japan)
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Symposium 11

Cutting Edge Science in Vascular Biology

10/26 (Tue.) 9:20-10:50 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Jianglin FAN(Department of Molecular Pathology, Faculty of Medicine, University of Yamanashi School of Medicine, Japan)
Karin BORNFELDT(Department of Medicine, University of Washington, USA)
"B Lymphocyte Regulation of Atherosclerosis"
Coleen MCNAMARA(Medicine/Cardiovascular Division, Beirne B. Carter /Immunology and Director, Carter Immunology Center, USA)
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"Interfering With Neutrophil Extracellular Traps (NETs) in Lower Extremity Arterial Thrombosis"
Yvonne DÖRING(Department for BioMedical Research (DBMR), University of Bern, Switzerland)
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"Cardiovascular Innovation: a Systems Approach to Target Discovery for Macrophage Activation and Inflammatory Vascular Disease"
Masanori AIKAWA(Brigham And Women's Hospital, Harvard Medical School, USA)
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"Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apoe Knock-Out Mice"
Manabu MINAMI(Department of Data Science, National Cerebral and Cardiovascular Center, Japan)
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"Atherosclerosis and Cardiovascular Disease Associated with Type 1 Diabetes"
Karin BORNFELDT(Department of Medicine, University of Washington, USA)
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Symposium 12

"Lipid" Recent Progress in Apolipoprotein Research

10/26 (Tue.) 9:20-10:50 (JST) Room 2 (ICC Kyoto Room A)

Chair
Takashi MIIDA(Department Of Clinical Laboratory Medicine, Juntendo University, Japan)
Gissette REYES-SOFFER(Department of Medicine, Columbia University Irving Medical Center, Columbia College of Physicians and Surgeons, USA)
Kasey VICKERS(Department of Medicine, Vandervilt University Medical Center, USA)
"Early Diagnostics and Risk Stratification of Pancreatic Cancer Using Aberrant Truncation of C-Terminus Apolipoprotein A2 Homodimer"
Kazufumi HONDA(Department of Bioregulation, Graduate School of Medicine, Nippon Medical School, Japan)
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"Understanding the Relationship of Apo CIII with Cardiovascular Disease"
Gissette REYES-SOFFER(Department of Medicine, Columbia University Irving Medical Center, Columbia College of Physicians and Surgeons, USA)
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"Apolipoprotein C-II And C-III as Nutritional Markers"
Satoshi HIRAYAMA(Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Japan)
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Symposium 13

"Innovation"
Clinical Impacts of Innovative New Drugs and Therapeutics: Evidences vs. Real World

10/26 (Tue.) 9:20-10:50 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Lale TOKGÖZOGLU(Department of Cardiology, Hacettepe University, Turkey)
Toyoaki MUROHARA(Department of Cardiology, Nagoya University, Japan)
"Volanesorsen-Mediated Lowering of Plasma Triglyceride Levels in Patients with Familial Chylomicronaemia Syndrome (FCS) through Inhibition of Apolipoprotein C-III (APOC3)"
John KASTELEIN(Department of Vascular Medicine, University of Amsterdam, The Netherlands)
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"Roles of Factor Xa Inhibitors for Atherosclerosis and Peripheral Arterial Diseases"
Marc BONACA(Department of Cardiology And Vascular Medicine, CPC / University of Colorado SOM, USA)
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"Impact of Anti-Inflammatory Therapy for Atherosclerotic Disease"
Paul M. RIDKER(Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, USA)
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"Plasmid DNA-Based Gene Therapy from Vascular Regeneration to DNA Vaccine"
Ryuichi MORISHITA(Department of Cardiology and Cardiovascular Medicine, Osaka University, Japan)
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Symposium 14

"Lipid" Atherosclerotic Lesions -Smooth Muscle Cells, Macrophages and ECM

10/26 (Tue.) 11:00-12:30 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Yukihiko UEDA(Hirakata Kohsai Hospital, Japan)
Shuri KANEYAMA(Department of Biochemistry, Showa University, Japan)
"Update on Inflammation in Atherosclerosis"
Peter LIBBY(Cardiovascular Specialist, Brigham and Womens Hospital, and Mallinckrodt Professor of Medicine, Harvard Medical School, USA)
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"Defective Intracellular Protease Systems in Atherosclerosis"
Akira MIYAZAKI(Department of Biochemistry, Showa University School of Medicine, Japan)
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"Elucidation of the Role of miR-33a/b in Atherosclerosis and Obesity. Contrast between Central and Peripheral Roles."
Koh ONO(Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan)
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Symposium 15

Gender & Atherosclerosis

10/26 (Tue.) 11:00-12:30 (JST) Room 2 (ICC Kyoto Room A)

Chair
Jennifer ROBINSON(Department of Epidemiology, University of Iowa, USA)
Masahiro AKISHITA(Department of Geriatric Medicine, The University of Tokyo, Japan)
"Primary and Secondary ASCVD Prevention in Women"
Karol WATSON(Department of Medicine/Cardiology, University of California, Los Angeles, USA)
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"Sex, Menopause, and Coronary Atherosclerosis: Why Do More Women Have Inoca (Ischemia with No Obstructive CAD)?"
C Noel BAIREY MERZ(Smidt Heart Institute, Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, USA)
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"Dynamic Change of Relation Between T cells and Endothelial Cells for Atherosclerosis Risk in Perimenopausal Women"
Kayoko SATO(Department of Cardiology, Tokyo Women's Medical University, Japan)
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Symposium 16

"Thrombosis" Thrombotic and Hemorrhagic Disorders"

10/26 (Tue.) 11:00-12:30 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Eriko MORISHITA(Kanazawa University, Japan)
Nigel MACKMAN(Department of Medicine, The University of North Carolina at Chapel Hill, USA)
"Transformation of Silent Atherosclerosis Into Cardiovascular Events: Novel Mechanisms in Atherothrombosis"
Lina BADIMON(Department of Cardiovascular Sciences, IR-Hospital De Sant Pau, SPAIN)
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"Detection and Safety Prevention of Deep Vein Thrombosis"
Atsushi YAMASHITA(Department of Pathology, Miyazaki University, Japan)
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"Mechanisms of Cancer-Associated Thrombosis"
Nigel MACKMAN(Department of Medicine, The University of North Carolina at Chapel Hill, USA)
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"Cardiovascular Disease-Associated Acquired Von Willebrand Syndrome and Gastrointestinal Angiodysplasia"
Hisanori HORIUCHI(Department of Molecular and Cellular Biology, Tohoku Univeristy, Japan)
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Symposium 17

"Diabetes" Current Clinical Evidence on Prevention of Diabetic Complications

10/26 (Tue.) 13:50-15:20 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Amira AL KHARUSI(Department of Endocrinology, Ministry of Health, Oman)
Masaya KOSHIZAKA(Department of Diabetes, Metabolism and Endocrinology, Chiba University, Japan)
"Impact of Obesity and Diabetes in the Middle East"
Amira AL KHARUSI(Department of Endocrinology, Ministry of Health, Oman)
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"Effect of Diabetic Drug Therapy (RCT and Real-World Evidence)"
Masaya KOSHIZAKA(Department of Diabetes, Metabolism and Endocrinology, Chiba University, Japan)
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"Effect of Multifactorial Intervention on Diabetic Complications"
Kohjiro UEKI(Diabetes Research Center, National Center for Global Health and Medicine, Japan)
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"Intensive Lipid Lowering in Japan: The Empathy (Intensive Treat-To-Target Statin Therapy in High-Risk Japanese Patients with Hypercholesterolemia and Diabetic Retinopathy) Study"
Hiroshi ITOH(Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Japan)
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"Apolipoprotein B-48 as a Maker of Chylomicron Metabolism in Diabetes"
Kyoko INAGAKI(Department of Endocrinology, Diabetes and Metabolism, Nippon Medical School, Japan)
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Symposium 18

"Cardiovascular Disease/Thrombosis"
Updated of Pharmacological Therapy for Hyperlipidemia

10/26 (Tue.) 13:50-15:20 (JST) Room 2 (ICC Kyoto Room A)

Chair
Kenichi TSUJITA(Department of Cardiovascular Medicine, Kumamoto University, Japan)
Kayoko SATO(Department of Cardiology, Tokyo Women's Medical University, Japan)
"Anti-Atherosclerosis of Omega-3 PUFA: Improvement of Lipid Profile and Anti-Inflammation"
Hiroshi ITO(Department of Cardiovascular Medicine, Okayama University, Japan)
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"Clinical Significance of Ezetimibe as An Additional LDL-C Lowering Agent onto Baseline Statin Treatment in Secondary Prevention"
Kenichi TSUJITA(Department of Cardiovascular Medicine, Kumamoto University, Japan)
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"PCSK9 Inhibitors: Management of High-Risk for Cardiovascular Disease"
Atsushi NOHARA(Department of Clinical Genetics, Ishikawa Prefectural Central Hospital, Japan)
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"From Fibrates to SPPARMα: A New Challenge to Residual Cardiovascular Risk"
Koutaro YOKOTE(Department of Diabetes, Metabolism & Endocrinology, Chiba University Graduate School of Medicine, Japan)
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"Impact of Omega-3 Fatty Acids on Cardiovascular Risk: Reconciling Findings of Recent Trials for Clinical Practice"
Stephen NICHOLLS(Victorian Heart Institute, Monash University, Australia)
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Symposium 19

"HDL" Recent Progress in Apolipoprotein Research

10/26 (Tue.) 16:30-18:00 (JST) Room 2 (ICC Kyoto Room A)

Chair
Cesare SIRTORI(University of Milano and Dyslipidemia Clinic, ASST Niguarda Hospital, Italy)
Mika HORI(Research Institute of Environmental Medicine, Nagoya University, Japan)
"Structure-Function Relationship of HDL in Diabetes and Atherosclerosis"
Arnold VON ECKARDSTEIN(Institute of Clinical Chemistry, University of Zurich, Switzerland)
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"HDL-Targeted Gene Transfer and Apo A-I Nanoparticles for Treatment of Heart Failure"
Bart DE GEEST(Medicine Katholieke Universiteit Leuven, Belgium)
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"Transgenders, Gonadal Hormones and HDL"
Massimiliano RUSCICA(Department of Pharmacological and Biomolecular Sciences, Università Degli Studi Di Milano, Italy)
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"Evaluation of HDL Functionality and Cardiovascular Events"
Ken-ichi HIRATA(Department of Internal Medicine, Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan)
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"HDL/APOA-I(Milano) Based-Therapy: Would the Delivery Route Improve the Therapeutic Potential?"
Roberto GIOVANNONI(Department of Biology, University of Pisa, Italy)
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Symposium 20

"Hypertension/Kidney Disease" Kidney Disease: CKD and Anemia; HIF and Iron"

10/26 (Tue.) 16:30-18:00 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Motoko YANAGITA(Department of Nephrology, Graduate School of Medicine, Kyoto University, Japan)
Kunitoshi ISEKI(Nakamura Clinic, Japan)
"Management of Anemia in CKD Patients"
Sydney TANG(Department of Medicine, The University of Hong Kong, China)
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"Effects of PHD inhibitors in Kidney Fibrosis"
Masaomi NANGAKU(Division of Nephrology and Endocrinology, The University of Tokyo, Japan)
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"The Optimal Dose of Intravenous Iron Required for Patients on Haemodialysis"
David C WHEELER(University College of London, UK)
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"ESA in CKD Patients"
Takayuki HAMANO(Nagoya City University Hospital, Japan)
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Symposium 21

Lipoprotein (a) from Biology to Therapy

10/26 (Tue.) 18:10-19:40 (JST) Room 2 (ICC Kyoto Room A)

Chair
Gilles LAMBERT(Université de La Réunion, France)
Satoshi FUJII(Department of Laboratory Medicine, Asahikawa Medical University, Japan)
"The Mysteries of Lipoprotein(a) Metabolism: Identification of Knowledge Gaps and Future Research Priorities"
Marlys KOSCHINSKY(Robarts Research Institute, The University of Western Ontario, Canada)
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"Genetics and Epidemiology of Lp(a): New Findings beyond the Apo(a) Size Polymorphism and its Influence on Cardiovascular Disease"
Florian KRONENBERG(Institute of Genetic Epidemiology, Medical University of Innsbruck, Austria)
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"Lp(a) and Inflammation"
Samia MORA(Harvard Medical School, Brigham And Women's Hospital, USA)
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"Harmonization of Lipoprotein (a) Measurements"
Hiroshi YOSHIDA(Department of Laboratory Medicine, The Jikei University, Kashiwa Hospital, Japan)
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"Molecular Determinants of Lipoprotein (a) Lowering by PCSK9 Inhibitors"
Gilles LAMBERT(Université de La Reunion, France)
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Symposium 22

Omics Approach Toward Understanding Atherosclerosis

10/27 (Wed.) 8:40-10:10 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Ichiro MANABE(Chiba University, Japan)
Gabriela Alicia BERG(Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina)
"Macrophage Diversity in the Organ Crosstalk and Multimorbidity"
Ichiro MANABE(Chiba University, Japan)
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"Novel Insights into Epicardial Adipose Tissue Lipidomics on Coronary Artery Disease"
Gabriela Alicia BERG(Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina)
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"Small Dense LDL Preferentially Transport Proinflammatory Lipids in Hypertriglyceridemia"
John Martin CHAPMAN(Department of Endocrinology-Metabolism, Sorbonne University, France)
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Symposium 23

Cancer & Atherosclerosis

10/27 (Wed.) 8:40-10:10 (JST) Room 2 (ICC Kyoto Room A)

Chair
Kathryn MOORE(Department of Medicine, New York University, USA)
Hiroshi AKAZAWA(Department of Cardiovascular Medicine, The University of Tokyo Hospital, Japan)
"Myocardial Infarction Accelerates Breast Cancer via Innate Immune Reprogramming"
Kathryn MOORE(Department of Medicine, New York University, USA)
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"Cardio-Oncology: An Interdisciplinary Research Opportunity to Link Cancer, Aging, and Atherosclerosis in the Era of Precision Medicine"
Kazuhiro SASE(Department of Clinical Pharmacology and Regulatory Science, Juntendo University, Japan)
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"Clonal Hematopoiesis Connecting Cancer and Atherosclerosis"
Pradeep NATARAJAN(Department of Medicine, Cardiology, Massachusetts General Hospital, USA)
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"Cardiovascular Complications in Immune Checkpoint Inhibition Therapy"
Kazuko TAJIRI(Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan)
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Symposium 24

Atherosclerosis as a Chronic Inflammation

10/27 (Wed.) 8:40-10:10 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Elena AIKAWA(Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, USA)
Jianglin FAN(Department of Molecular Pathology, Faculty of Medicine, University of Yamanashi School of Medicine, Japan)
"Role of Neutrophil Citrullination in Atherosclerosis"
Masayuki YOSHIDA(Tokyo Medical and Dental University, Japan)
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"Role of T-Cell Cholesterol Efflux Pathways in Aging and Atherosclerosis"
Marit WESTERTERP(Department of Pediatrics, University Medical Center Groningen, The Netherlands)
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"Valve Calcification"
Elena AIKAWA(Department of Cardiovascular Medicine, Brigham And Women's Hospital, Harvard Medical School)
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"SAA and Conditional SR-BI Null Mice"
Maki TSUJITA(Department of Biochemistry, Nagoya City University, Japan)
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Symposium 25

"Imaging/Device" Development of Noninvasive Atherosclerotic Imaging

10/27 (Wed.) 10:20-11:50 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Sadako MOTOYAMA-TANIZAWA(Fujita Health University, Japan)
Bon-Kwon KOO(Seoul National University Hospital, ROK)
"Comprehensive Coronary Plaque Assessment by Coronary CT Angiography"
Shinichiro FUJIMOTO(Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Japan)
Photo
"Future of FFRCT Technology"
Bon-Kwon KOO(Seoul National University Hospital, ROK)
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"Non-invasive MR & MRA Technologies will Open up New Areas for Diagnosis and Treatment of Coronary Artery Disease"
Teruo NOGUCHI(National Cerebral and Cardiovascular Center, Japan)
Photo
Jagat NARULA(Department of Cardiology, Mount Sinai Hospital Morningside, USA)

Symposium 26

""Lipid" Bioactive Phospholipid and Fatty Acids"

10/27 (Wed.) 10:20-11:50 (JST) Room 2 (ICC Kyoto Room A)

Chair
Yutaka YATOMI(The University of Tokyo, Japan)
Sumiko ABE-DOHMAE(Chubu University, Japan)
"Advanced Non-Targeted Lipidomics and Its Application to Vascular Biology"
Makoto ARITA(Graduate School of Pharmaceutical Sciences, Keio University, Japan)
Photo
"Pleiotropic Effects of HDL via Apolipoprotein M/Sphingosine 1-Phosphate Axis"
Makoto KURANO(Department of Clinical Laboratory Medicine, The University of Tokyo, Japan)
Photo
"The Role of Phosphatidylinositol Acyl Chains in Nonalcoholic Fatty Liver Disease"
Nozomu KONO(The University of Tokyo, Japan)
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"CtBP2 Serves as a Metabolite Sensor Critically Involved in the Maintenance of Hepatic Glucose and Lipid Homeostasis"
Motohiro SEKIYA(University of Tsukuba, Japan)
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Symposium 27

"Nutrition" Dietary Pattern and Lipids

10/27 (Wed.) 10:20-11:50 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Erin MICHOS(Department of Cardiology, Johns Hopkins University School of Medicine, USA)
Minoru TAKEMOTO(Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Japan)
"The Japanese Diet, Outcome, and a GWAS on Preference for It"
Yasuyuki NAKAMURA(Department of Public Health, Shiga University of Medical Science, Japan)
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"Omega-3 Fatty Acids and Hypertriglyceridemia: A Science Advisory from the American Heart Association"
Ann C. SKULAS-RAY(Department of Nutritional Sciences, the University of Arizona, USA)
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"Impact of Serum Concentration of Trans-Fatty Acids on Cardiovascular Disease in Japan"
Tatsuro ISHIDA(Department of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan)
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"Vitamin Supplementation in the 21st Century: Helpful, Harmful or Neutral for Cardiovascular Health?"
Erin MICHOS(Department of Cardiology, Johns Hopkins University School of Medicine, USA)
Photo

Symposium 28

"Imaging/Device" Vulnerable Plaques and Intravascular Imaging

10/27 (Wed.) 13:10-14:40 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Khurram NASIR(Houston Methodist Hospital, USA)
Taishi YONETSU(Tokyo Medical and Dental University, Japan)
"Gray Scale Ivus Assessment of Vulnerable Plaques"
Kenichi FUJII(Kansai Medical University, Japan)
Photo
"Oct Assessment of Vulnerable Plaques"
Myong Hwa YAMAMOTO(Division of Cardiology, Showa University Northern Yokohama Hospital, Japan)
Photo
"NIRS-IVUS Assessment of Vulnerable Plaques: Comparison with IVUS, OCT and CCTA"
Tomotaka DOHI(Juntendo University, Japan)
Photo
"Pathologic Insights into the Visualization of Vulnerable Plaques by Intracoronary Imaging Modalities"
Fumiyuki OTSUKA(Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Japan)
Photo

Symposium 29

"Hypertension/ Kidney Disease"
Hypertension: Vascular Stiffness and Cardiovascular Outcome

10/27 (Wed.) 13:10-14:40 (JST) Room 2 (ICC Kyoto Room A)

Chair
Hirofumi TOMIYAMA(Department of Cardiology, Tokyo Medical University, Japan)
Seiji UMEMOTO(Araki Neurosurgical Hospital, Japan)
"In-Office and Out-of-Office Blood Pressure Variability as Cardiovascular Risk Factor"
Kei ASAYAMA(Department of Hygiene and Public Health, Teikyo University School of Medicine)
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"Effects of Lifelong Low-Salt and High-Potassium Diet on Blood Pressure, Arterial Stiffness, and Left Ventricular Function"
Akio ISHIDA(Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Graduate School of Medicine, Japan)
Photo
"Abnormal Hemodynamics in an Arterial Tree: A Key Element for Cardiovascular Outcomes in Hypertension"
Hirofumi TOMIYAMA(Department of Cardiology, Tokyo Medical University, Japan)
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Symposium 30

Visceral Fat, Atherosclerosis, and Cardiometabolic Disease

10/27 (Wed.) 14:50-16:20 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Yuji MATSUZAWA(Sumitomo Hospital, Japan)
Hidenori ARAI(National Center for Geriatrics and Gerontology, Japan)
"Visceral and Ectopic Fat in Relation to Cardiovascular Disease"
Jacob C SEIDELL(Department of Health Sciences, Vrije Universiteit, Amsterdam, Netherlands)
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"Liver Fat Accumulation and Cardiovascular Disease Risk: Is PCSK9 a Link?"
Paolo MAGNI(Department of Pharmacological and Biomolecular Sciences, Universita' degli Studi di Milano, and IRCCS MultiMedica, Milan, Italy)
Photo
"Impact of Liver Fat on the Differential Partitioning of Hepatic Triacylglycerol into VLDL Subclasses on High and Low Sugar Diets"
Bruce A. GRIFFIN(Nutritional Metabolism, Faculty of Health & Medical Sciences, University of Surrey, UK)
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"Emerging Issue of Sarcopenic Obesity on Cardiovascular Disease: Message From a Super-Aging Society"
Hidenori ARAI(National Center for Geriatrics and Gerontology, Japan)
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Symposium 31

"Epidemiology Big Data"
Epidemiology for Atherosclerotic Diseases in Asian Populations: History and Future Direction

10/27 (Wed.) 14:50-16:20 (JST) Room 2 (ICC Kyoto Room A)

"Cardiovascular Epidemiology in Japan: Update"
Hiroyasu ISO(Osaka University Graduate School of Medicine, Japan)
Photo
"Epidemiology of Atherosclerosis and Coronary Heart Disease Comparing Japan and the Us and Future Opportunities in The Era of Big Data"
Akira SEKIKAWA(NHLBI T32 Cardiovascular Training Program,
Graduate School of Public Health, University of Pittsburgh, USA)
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"Big Data Can Enhance Randomised Trials but Not Replace Them"
Jane ARMITAGE(Oxford University, UK)
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Symposium 32

"Stroke" Lipid Management for Stroke Prevention

10/27 (Wed.) 16:30-18:00 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Masayasu MATSUMOTO(Department of Neurology, Ikeda City Hospital, Japan)
Pierre AMARENCO(Paris University, France)
"Hypercholesterolemia as a Risk Factor for Stroke Incidence and Recurrence in Japan: Findings From the Hisayama Study and the Fukuoka StrokeRegistry"
Jun HATA(Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Japan)
Photo
"Lipid Management for Stroke Prevention in Japan: Lessons from J-STARS"
Naohisa HOSOMI(Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Japan)
Photo
Pierre AMARENCO(Paris University, France)
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Yoshihiro KOKUBO(National Cerebral and Cardiovascular Center, Japan)

Symposium 33

"Stroke" Novel Therapeutic Approach for Stroke

10/27 (Wed.) 18:10-19:40 (JST) Room 1 (ICC Kyoto Annex Hall)

Chair
Aya HIGASHIYAMA(Department of Hygiene, School of Medicine, Wakayama Medical University, Japan)
"Suita Score and Preventive Approach for Stroke with Management of Emerging Risk Factors"
Aya HIGASHIYAMA(Department of Hygiene, School of Medicine, Wakayama Medical University, Japan)
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"Genotype and Risk Factors for Intracranial Atherosclerosis in Japan"
Shuhei OKAZAKI(Department of Neurology, Osaka University Graduate School of Medicine, Japan)
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"A New Era for Stroke Treatment- Endovascular Therapy: Progress and Current Topics"
Hiroshi YAMAGAMI(Department of Stroke Neurology, National Hospital Organization Osaka National Hospital, Japan)
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"Anti-Inflammatory Strategy for Secondary Stroke Prevention: Findings in Japan"
Kazuo KITAGAWA(Tokyo Women's Medical University, Japan)
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Symposium 34

"Imaging/Device"
Optimal Management of High-risk Percutaneous Coronary Intervention

10/27 (Wed.) 18:10-19:40 (JST) Room 2 (ICC Kyoto Room A)

Chair
Junya AKO(Department of Cardiovascular Medicine, Kitasato University, Japan)
Mirvat ALASNAG(Department of Cardiovascular, King Fahd Armed Forces Hospital, Saudi Arabia)
"Atherosclerosis In Women (& Disparity in Clinical Care)"
Mirvat ALASNAG(Department of Cardiovascular, King Fahd Armed Forces Hospital, Saudi Arabia)
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"Management of Cardiogenic Shock in Acute Myocardial Infarction"
Tetsuya MATOBA(Department of Cardiovascular Medicine, Kyushu University Hospital, Japan)
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"Detection of Vulnerable Plaque"
Gaku NAKAZAWA(Department of Cardiology, Kindai University Faculty of Medicine, Japan)
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"The Current Status and Future Prospects of Imaging Guided Peripheral Arterial Interventions"
Tatsuya NAKAMA(Department of Cardiology, Tokyo Bay Medical Center, Japan)
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Symposium 35

"Pediatric" Familial Hypercholesterolemia (FH) in Children and Young Adults

10/27 (Wed.) 18:10-19:40 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Akira OHTAKE(Department of Pediatrics and Clinical Genomics, Saitama Medical University, Japan)
Uma RAMASWAMI(Royal Free London NHS Foundation Trust, UK)
"Changes in Serum Cholesterol Levels in Children and its Tracking to Adults"
Eri OSAWA(Department of International Health and Collaboration, National Institute of Public Health)
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"Diagnosis, Treatment and Mutation Spectrum of Paediatric Familial Hypercholesterolaemia: Data From Eight European Countries"
Uma RAMASWAMI(Royal Free London NHS Foundation Trust, UK)
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"Screening and Management of Pediatric Familial Hypercholesterolemia in Slovenia and Europe"
Urh GROSELJ(University Children's Hospital Ljubljana, UMC Ljubljana, Slovenia)
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"Genetic Analysis for The Diagnosis of FH Children"
Keiko NAGAHARA(Department of Pediatrics, Showa University School of Medicine, Japan)
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"Early Diagnosis and Treatment of Familial Hypercholesterolemia in Young Adults"
Sachiko OKAZAKI(The University of Tokyo Hospital, Japan)
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Joint Symposium

APSAVD-IAS-JAS Joint Symposium Sponsored:
Kowa Company, Ltd

Evidence of Triglyceride-rich Lipoproteins and Remnant Cholesterol for Residual Cardiovascular Risk Management.

10/25 (Mon.) 13:00-15:00 (JST) Room 2 (ICC Kyoto Room A)

Chair
Hidenori ARAI(National Center for Geriatrics and Gerontology, Japan)
Richard O’BRIEN(Clinical Dean of Medicine, University of Melbourne, Australia)
"The Origins and Fates of Triglyceride-Rich Lipoproteins and Their Remnants: Why Do Some People Accumulate Atherogenic Remnants?"
Henry N GINSBERG(Irving Professor of Medicine and Past Director, Irving Institute for Clinical and Translational Research, Columbia University, USA)
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"Clinical Relevance of Triglyceride-Rich Lipoproteins and Remnant Cholesterol"
Børge G NORDESTGAARD(Clinical Professor, Department of Clinical Medicine, University of Copenhagen／Chief Physician, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark)
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"Remnant Cholesterol (RC) and ASCVD: Evidence, Mechanisms and Current Status"
Jian-Jun LI(Professor and Director, Center for Dyslipidemia and Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China)
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"Multicenter Clinical Study for the Examination of Apolipoprotein B-48 Level as a Screening Marker for Coronary Artery Disease"
Daisaku MASUDA(Rinku General Medical Center, Rinku Innovation Center for Wellness Care and Activities/ Health Care Center /Department of Cardiology, Japan)
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"Management of Diabetic Dyslipidemia"
Brian TOMLINSON(Professor, Faculty of Medicine, Macau University of Science and Technology, China)
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Alberico L CATAPANO(Professor, Department of Pharmacological and Biomolecualr Sciences, University of Milan, Italy)

IAS-EAS-NLA-JAS Joint Symposium

Guideline

10/25 (Mon.) 16:00-17:30 (JST) Room 2 (ICC Kyoto Room A)

Chairs
Kausik RAY(Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, UK)
Kazuhisa TSUKAMOTO(Department of Internal Medicine, Teikyo University School of Medicine, Japan)
"Developing Guidance for Implementing Better Care of Familial Hypercholesterolemia"
Gerald WATTS(Cardiology and Internal Medicine, Royal Perth Hospital/ University of Western Australia, Australia)
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"ESC/EAS Dyslipidemia Guidelines"
Lale TOKGÖZOGLU(Department of Cardiology, Hacettepe University, Turkey)
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Joseph SASEEN(University of Colorado Anschutz Medical Campus, USA)
"Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017 and Its Scheduled Update in 2022 Based on Japanese Epidemiologic Studies."
Tomonori OKAMURA(Preventive Medicine and Public Health, Keio University School of Medicine, Japan)
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KSoLA-JAS Joint Symposium

Epigenomic Control of Immuno-Fat Metabolism in Obesity and Cardiovascular Disease

10/26 (Tue.) 13:50-15:20 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Juro SAKAI(Graduate School of Medicine , Tohoku University/ Research Center for Advanced Science and Technology, University of Tokyo, Japan)
"Transcriptional and Epigenetic Regulation of Macrophages"
Sungho PARK(Korea’s Ulsan National Institute of Science and Technology, ROK)
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"A Phosphatase Protein Complex Orchestrates Uncoupled Respiration via a Histone Demethylase and YAP/TAZ Mediated Actomyosin Pathway in White Adipose Tissue"
Juro SAKAI(Graduate School of Medicine , Tohoku University/ Research Center for Advanced Science and Technology, University of Tokyo, Japan)
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"Immunometabolic Regulation of Macrophages in Cardiovascular Disease"
Ichiro MANABE(Chiba University, Japan)
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"Systems biology of human metabolism - multi-omics based approaches"
Sunjae LEE(Gwangju Institute Of Science And Technology, ROK)
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Hypertriglyceridemia, Approach to the Residual Risk

10/27 (Wed.) 13:10-14:40 (JST) Room 3 (ICC Kyoto Room B-1)

Chair
Hideaki BUJO(Toho University Sakura Medical Center, Japan)
"Triglycerides and its Constituents as a Central Cardiometabolic Risk"
Tomohiro TANAKA(Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Japan)
"TyG index is a good predictor for future cardiovascular disease? "
Sung Hee CHOI(Department of Internal Medicine, Endocrinology & Metabolism, Seoul National University College of Medicine, ROK)
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"Treatment Strategy of Dyslipidemia Considering the Residual Risk"
Masaya KOSHIZAKA(Department of Diabetes, Metabolism and Endocrinology, Chiba University, Japan)
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"What If Triglyceride Levels Are Still High in Statin Users? – Real World Evidence"
Sin Gon KIM(Department of Endocrinology and Metabolism, Korea University College of Medicine, ROK)
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OSLA-IAS-JAS Joint Symposium

Gender Differences in the Prevalence and Management of Atherosclerotic Cardiovascular Diseases: International Prospective

10/27 (Wed.) 14:50-15:50 (JST) Room 3 (ICC Kyoto Room B-1)

Chairs
Wael ALMAHAMEED(Cleveland Clinic Abu Dhabi, UAE)
Masahiro AKISHITA(Department of Geriatric Medicine, The University of Tokyo, Japan)
Khalid AL-RASADI(College of Medicine and Health Sciences, Sultan Qaboos University, Oman)
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"Dyslipidemia and Gender Differences in APAC"
Yoko YAMADA(Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan)
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Raul SANTOS(Department of Cardiopneumology, Heart Institute (InCor) University of Sao Paulo Medical School Hospital and Hospital Israelita Albert Einstein, Brazil)

Satellite Symposium

The Dawn of a New Era for Screening, Diagnosis and Treatments for Pediatric FH
Flyer

To join ISA2021 Pediatric FH Satellite Symposium,
the registration to ISA2021 is required.

10/22 (Fri.) 17:00-20:30 (JST) Live

Opening

Speaker
"Welcome and dedication to Dr. Akira Yamamoto"
Mariko HARADA-SHIBA(Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Japan)

Screening of Pediatric FH, When and How

Chairs
Marta FUTEMA(UCL Institute of Cardiovascular Science, UK)
Shizuya YAMASHITA(Department of Cardiology, Rinku General Medical Center, Japan)
Speakers
"Universal Screening for Pediatric Familial Hypercholesterolemia in Slovenia"
Urh GROŠELJ(Universal Screening for Pediatric Familial Hypercholesterolemia in Slovenia, Slovenia)
"Universal Screening for Pediatric Familial Hypercholesterolemia in Kagawa, Japan"
Tetsuo MINAMINO(Universal Screening for Pediatric Familial Hypercholesterolemia in Kagawa, Japan)

What Can We Learn From the Genetics of FH and Sitosterolemia?

Chairs
Shinji YOKOYAMA(Institute for Biological Functions, Chubu University, Japan)
Atsushi NOHARA(Department of Clinical Genetics, Ishikawa Prefectural Central Hospital, Japan)
Speakers
"Mutation Spectrum and Genotype-Phenotype Analysis in Children With FH in the IAS FH Pediatric Register"
Marta FUTEMA(Mutation spectrum and genotype-phenotype analysis in children with FH in the IAS FH Pediatric Register, UK)
"Impact of Sitosterolemia as a Phenocopy of Homozygous and Heterozygous FH During Childhood"
Hayato TADA(Impact of sitosterolemia as a phenocopy of homozygous and heterozygous FH during childhood, Japan)

Treatment of Pediatric FH, From When and How?

Chairs
Mariko HARADA-SHIBA(Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Japan)
Raul SANTOS(The University of São Paulo (USP) Medical School, Brazil)
Speakers
"Efficacy and Safety of Evolocumab and PCSK9 Inhibition in Pediatric FH Patient"
Raul SANTOS(The University of São Paulo (USP) Medical School, Brazil)
"Importance and Safety of Long-term Lipid Lowering in Pediatric FH"
Albert WIEGMAN(University of Amsterdam, The Netherlands)

Closing

Speaker
Albert WIEGMAN(University of Amsterdam, The Netherlands)

Morning Seminar

Morning Seminar 1
MOCHIDA PHARMACEUTICAL CO., LTD

"Comprehensive lipid management in Coronary Artery Disease with highly purified EPA"

10/25 (Mon.) 7:30-8:30 (JST) Room 1 (Annex Hall)

Chair
Tohru MINAMINO(Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine)
Speaker
Kenichi TSUJITA(Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University)

Morning Seminar 2
AstraZeneca.KK

"SGLT2i, GLP-1RA and Obesity treatments"

10/27 (Wed.) 7:30-8:30 (JST) Room 1 (Annex Hall)

Chair
Fumitaka OKAJIMA(Nippon Medical School Chiba Hokusoh Hospital)
Speaker
Hiraku ONO(Chiba University)

Luncheon Seminar

Luncheon Seminar 1
Takeda Pharmaceutical Company Limited

"Roles of Triglyceride in Residual Risk of Cardiovascular Events"

10/25 (Mon.) 11:50-12:50 (JST) Room 1 (Annex Hall)

Chair
Masataka SATA(Professor, Department of Cardiovascular Medicine
Tokushima University Graduate School of Biomedical Sciences)
Speaker
Yukihito HIGASHI(Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University /
Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research
Hiroshima University Hospital)

Luncheon Seminar 2
Novartis Pharma K.K.

"Management of cardiovascular risk by comprehensive risk approach
especially from the cardiologist point of view"

10/25 (Mon.) 11:50-12:50 (JST) Room 2 (Room A)

Chair
Mariko HARADA-SHIBA(Department of Molecular Pathogenesis
National Cerebral and Cardiovascular Center Research Institute)
Speaker
Kouji KAJINAMI(Department of Cardiology, Kanazawa Medical University)

Luncheon Seminar 3
Nippon Boehringer Ingelheim Co., Ltd. /
Eli Lilly Japan K.K.

"Four practical approaches to reduce cardiovascular diseases in diabetic patients"

10/26 (Tue.) 12:40-13:40 (JST) Room 1 (Annex Hall)

Chair
Koutaro YOKOTE(Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine)
Speaker
Michio SHIMABUKURO(Department of Diabetes Endocrinology and Metabolism, Fukushima Medical University)

Luncheon Seminar 4
Sysmex Corporation

"Current Status and Future Perspective of HDL Functions"

10/26 (Tue.) 12:40-13:40 (JST) Room 2 (ICC Kyoto Room A)

Chair
Ken-ichi HIRATA(Department of Internal Medicine, Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan)
Speaker
Katsunori IKEWAKI(Division of Neurology, Anti-Aging, and Vascular Medicine
National Defense Medical College)

Luncheon Seminar 5
Takeda Pharmaceutical Company Limited

"Intervention for hypertriglyceridemia to combat residual risk for cardiovascular disease"

10/27 (Wed.) 12:00-13:00 (JST) Room 1 (Annex Hall)

Chair
Masayuki YOSHIDA(Professor, Tokyo Medical and Dental University,
Department of Life sciences and Bioethics)
Speaker
Hayato TADA(Assistant Professor,
Kanazawa University Graduate School of Medical Sciences,
Department of Cardiovascular Medicine)

Luncheon Seminar 6
Amgen K.K./ Astellas Pharma Inc.

"Familial hypercholesterolemia and PCSK9 inhibitor"

10/27 (Wed.) 12:00-13:00 (JST) Room 2 (Room A)

Chair
Masaaki MIYATA(School of Health Sciences, Faculty of Medicine, Kagoshima University)
Speaker
Mariko HARADA-SHIBA(Department of Molecular Pathogenesis, National Cerebral & Cardiovascular Center Research Institute)

Luncheon Seminar 7
Novartis Pharma K.K.

"The importance of management of cardiovascular risk factors"

10/27 (Wed.) 12:00-13:00 (JST) Room 3 (Room B-1)

Chair
Naoyuki HASEBE(Asahikawa Medical University)
Speaker
Ken-ichi HIRATA(Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan)

Sponsored Symposium

Sponsored Symposium 1
Fukuda Denshi Co., Ltd.

10/25 (Mon.) 17:40-19:10 (JST) Room 1 (Annex Hall)

Chairs
Shigeo HORINAKA, MD(Professor of Department of Cardiovascular Medicine, Dokkyo Medical University, Tochigi, Japan)
Kohji SHIRAI, MD(Emeritus professor of Toho University / Mihama hospital, Chiba, Japan)
Opening
Shigeo HORINAKA(Professor of Department of Cardiovascular Medicine, Dokkyo Medical University, Tochigi, Japan)
Speakers
"CAVI & Atherosclerosis Longitudinal Studies in Thailand"
Piyamitr Sritara MD, FRCP(London), FACP(Professor of Medicine, Dean, Facurity of Medicine,
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand)
"Prognostic Significance of CAVI in Idiopathic Pulmonary Arterial Hypertension"
Yuriy SIRENKO, MD(Head of Department, Strazhesko Institute of Cardiology, National Academy of Medical Science of Ukraine, Kiev, Ukraine)
"Adoption of "A Body Shape Index (ABSI)" in the Diagnosis of Metabolic Syndrome Contributes to the Prediction of Renal Function Decline: Irrationality of Waist Circumference"
Daiji NAGAYAMA, MD(Department of Internal Medicine, Nagayama Clinic, Tochigi, Japan Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center, Chiba, Japan)
"Acute Enhancement of CAVI as a Predictor of Impending Cardiovascular Events : Smooth Muscle Cell Contraction for Plaque Rupture"
Kohji SHIRAI, MD(Emeritus professor of Toho University / Mihama hospital, Chiba, Japan)
"Cadio-Ankle Vascular Index (CAVI) Beyond Atherosclerosis"
Roland ASMAR, MD(Chairman, Foundation-Medical Research Institutes. Geneva Switzerland)
Closing
Roland ASMAR, MD(Chairman, Foundation-Medical Research Institutes. Geneva Switzerland)

Sponsored Symposium 2
Kowa Company, Ltd.

10/26 (Tue.) 16:30-18:00 (JST) Room 1 (Annex Hall)

Chairs
Shizuya YAMASHITA(President, Rinku General Medical Center, Japan)
Jean-Charles FRUCHART(President, R3i Foundation, Switzerland)
Opening
Shizuya YAMASHITA(President, Rinku General Medical Center, Japan)
Speakers
"Future perspectives on the management of triglyceride and residual risk"
Koutaro YOKOTE(Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Japan)
"Risk of atherosclerosis associated with elevated non-fasting triglycerides"
Børge G. NORDESTGAARD(Clinical Professor, Department of Clinical Medicine, University of Copenhagen/
Chief Physician, Depertment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark)
"What is to be addressed by the PROMINENT Study?"
Paul M RIDKER(Eugene Braunwald Professor of Medicine, Harvard Medical School/
Directer, Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, USA)
Closing
Jean-Charles FRUCHART(President, R3i Foundation, Switzerland)