Nara Multidisciplinary approach for well-being

Speaker

Takashi Kawano

Curriculum Vitae

PERSONAL INFORNATION

Name Takashi Kawano, M.D., Ph.D
Date of Birth April 30, 1972
Place of Birth Japan
Sex Male
Nationality Tokushima, Japanese

EDUCATION AND PROFESSIONAL TRAINING

2017-present Associate Professor, Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Japan
2010-2017 Assistant Professor, Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Nankoku, Japan
2008-2009 Research fellow, Department of Anesthesiology, Medical College of Wisconsin
2005-2008 Instructor, Department of Anesthesiology, Tokushima University Hospital, Japan
2003-2005 Resident, Department of Anesthesiology, Tokushima University Hospital, Japan
2003 Ph.D. Tokushima University, Medical School, Japan
1998 M.D. Kochi Medical School Japanese Medical License Registration (NO. 394269)

SCIENTIFIC SKILLS

  • Animal surgery (neuropathic pain model, abdominal surgery)
  • Animal behavior (pain, cognitive, sedation)
  • Patch-clamp configuration
  • Site-directed mutagenesis
  • Cell culture, transfection

RESERCH FIELDS

  • Mechanisms of postoperative cognitive dysfunction
  • Aging and anesthesia
  • Mechanisms of neuropathic pain
  • Effects and molecular mechanisms of anesthetics on KATP channels

ENGRISH PUBLICATIONS

  1. Tsutsumi Y, Oshita S, Kitahata H, Kuroda Y, Kawano T, Nakaya Y. Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes. Anesthesiology 92: 1154-9, 2000
  2. Tsutsumi Y, Oshita S, Kawano T, Kitahata H, Tomiyama Y, Kuroda Y, Nakaya Y. Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes. Anesthesiology 95: 766-70, 2001
  3. Kawano T, Oshita S, Tsutsumi Y, Tomiyama Y, Kitahata H, Kuroda Y, Takahashi A, Nakaya Y. Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes. Anesthesiology 96: 1472-7, 2002
  4. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tomiyama Y, Kitahata H, Kuroda Y, Nakaya Y. Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology 100: 338-46, 2004
  5. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tomiyama Y, Kitahata H, Kuroda Y, Nakaya Y. Molecular mechanisms of the inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on sarcolemmal adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Anesthesiology 101; 390-8, 2004.
  6. Kawano T, Oshita S, Takahashi A, Tsutsumi Y, Tanaka K, Tomiyama Y, Kitahata H, Nakaya Y. Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology 102; 93-101, 2005
  7. Nakamura A, Kawahito S, Kawano T, Nazari H, Takahashi A, Kitahata H, Nakaya Y, Oshita S. Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels. Anesthesiology 106; 515-22, 2007
  8. Tanaka K, Kawano T, Nakamura A, Nazari H, Kawahito S, Oshita S, Takahashi A, Nakaya Y. Isoflurane activates sarcolemmal adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells. Anesthesiology 106; 984-91, 2007
  9. Kawano T, Tanaka K, Nazari H, Oshita S, Takahashi A, Nakaya Y. The effects of extracellular pH on vasopressin inhibition of ATP-sensitive K+ channels in vascular smooth muscle cells. Anesth Analg 105; 1714-9, 2007
  10. Eguchi S, Kawano T, Yinhua, Tanaka K, Yasui S, Mawatari K, Takahashi A, Nakaya Y, Oshita S, Nakajo N. Effects of prostaglandin E1 on vascular ATP-sensitive potassium channels. J Cardiovasc Pharmacol 50; 686-91. 2007
  11. Kawano H, Kawano T, Tanaka K, Eguchi S, Takahashi A, Nakaya Y, Oshita S. Effects of dopamine on ATP-sensitive potassium channels in porcine coronary artery smooth-muscle cells. J Cardiovasc Pharmacol 51; 196-201, 2008
  12. Kawano T, Tanaka K, Mawatari K, Oshita S, Takahashi A, Nakaya Y. Hyperglycemia impairs isoflurane-induced ATP-sensitive potassium channel activation in vascular smooth muscle cells. Anesth Analg 106; 858-64, 2008
  13. Kawano T, Zoga V, Kimura M, Liang MY, Wu HE, Gemes G, McCallum JB, Kwok WM, Hogan QH, Sarantopoulos CD. Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons action by direct S-nitrosylation. Mol Pain 14; 12, 2009
  14. Kawano T, Zoga V, McCallum JB, Wu HE, Gemes G, Liang MY, Abram S, Kwok WM, Hogan QH, Sarantopoulos CD. ATP-Sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury. Neuroscience 162; 413-43, 2009
  15. Kawano T, Zoga V, Gemes G, McCallum JB, Wu HE, Pravdic D, Liang MY, Kwok WM, Hogan Q, Sarantopoulos C. Suppressed Ca2+/CaM/CaMKII-dependent KATP channel activity in primary afferent neurons mediates hyperalgesia after axotomy. Proc Natl Acad Sci U S A 106; 8725-30, 2009
  16. Tanaka K, Kawano T, Tomino T, Kawano H, Okada T, Oshita S, Takahashi A, Nakaya Y. Mechanisms of impaired glucose tolerance and insulin secretion during isoflurane anesthesia. Anesthesiology 111; 1044-51. 2009
  17. Zoga V, Kawano T, Liang MY, Bienengraeber M, Weihrauch D, McCallum B, Gemes G, Hogan Q, Sarantopoulos C. KATP channel subunits in rat dorsal root ganglia alterations by painful axotomy. Mol Pain 6; 6, 2010
  18. Kawano T, Tanaka K, Yin-hua, Eguchi S, Kawano H, Takahashi A, Nakaya Y, Oshita S. Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle. J Med Invest 57; 237-44, 2010
  19. Kawano T, Tanaka K, Chi H, Kimura M, Kawano H, Eguchi S, Oshita S. Effects of Aging on Isoflurane-induced and PKA-mediated Activation of KATP channels in Cultured Rat Aortic Vascular Smooth Muscle Cells. J Cardiovasc Pharmacol 56; 676-85. 2010
  20. Tanaka K, Kawano T, Tsutsumi YM, Kinoshita M, Kakuta N, Hirose K, Kimura M, Oshita S. Differential effects of propofol and isoflurane on glucose utilization and insulin secretion. Life Sci 88; 96-103, 2011
  21. Kawano T, Soga T, Chi H, Eguchi S, Yamazaki F, Kumagai N, Yokoyama M. Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats. J Anesth 25; 942-5, 2011
  22. Kawano T, Yokoyama M. Can sugammadex encapsulation eliminate the antigenic activity of amino-steroidal neuromuscular blocking agent? J Anesth 25; 953-4, 2011
  23. Kawahito S, Kawano T, Kitahata H, Oto J, Takahashi A, Harada N, Nakagawa T, Kinoshita H, Azuma T, Nakaya Y, Oshita S. Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels. Anesth Analg 113; 1374-80, 2011
  24. Kawano T, Soga T, Chi H, Eguchi S, Yamazaki F, Yokoyama M. The involvement of the neurosteroid allopregnanolone in the anti-hyperalgesic effect of paroxetine in a rat model of neuropathic pain. Neuroreport 22; 984-8, 2011
  25. Kawano T, Yamazaki F, Chi H, Kawahito S, Eguchi S. Dexmedetomidine directly inhibits vascular ATP-sensitive potassium channels. Life Sci 90; 272-7. 2012
  26. Kawano T, Tanaka K, Chi H, Eguchi S, Yamazaki F, Kitamura S, Kumagai N, Yokoyama M. Biophysical and Pharmacological Properties of Glucagon-like peptide-1 in Rats under Isoflurane Anesthesia. Anesth Analg 115; 62-9, 2012
  27. Chi H, Kawano T, Tamura T, Iwata H, Takahashi Y, Eguchi S, Yamazaki F, Kumagai N, Yokoyama M. Postoperative pain impairs subsequent performance on a spatial memory task via effects on N-methyl-d-aspartate receptor in aged rats. Life Sci 93; 986-93, 2013
  28. Kawano T, Takahashi T, Iwata H, Morikawa A, Imori S, Waki S, Tamura T, Yamazaki F, Eguchi S, Kumagai N, Yokoyama M. Effects of ketoprofen for prevention of postoperative cognitive dysfunction in aged rats. J Anesth 6; 932-6, 2014
  29. Kawano T, Morikawa A, Imori S, Waki S, Tamura T, Yamanaka D, Yamazaki F, Yokoyama M. Preventive effects of multisensory rehabilitation on development of cognitive dysfunction following systemic inflammation in aged rats. J Anesth 28; 780-4, 2014
  30. Kawano T, Eguchi S, Iwata H, Tamura T, Kumagai N, Yokoyama M. Impact of Preoperative Environmental Enrichment on Prevention of Development of Cognitive Impairment following Abdominal Surgery in a Rat Model. Anesthesiology 123; 160-70, 2015
  31. Kawano T, Eguchi S, Iwata H, Yamanaka D, Tateiwa H, Locatelli FM, Yokoyama M. Effects and underlying mechanisms of endotoxemia on post-incisional pain in rats. Life Sci 148;145-53, 2016
  32. Kawano T, Eguchi S, Iwata H, Yamanaka D, Tateiwa H, Locatelli FM, Yokoyama M. Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats. Life Sci 148; 211-9, 2016
  33. Kawano T, Iwata H, Aoyama B, Nishigaki A, Yamanaka D, Tateiwa H, Eguchi S, Locatelli FM, Yokoyama M. The role of hippocampal insulin signaling on postoperative cognitive dysfunction in an aged rat model of abdominal surgery. Life Sc. 162; 87-94, 2016

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